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Volume 177 , 1 August 2017, Pages 228-236 Cigarette smoking is associated with amplified age-related volume loss in subcortical brain regions Author links open overlay panel Timothy C.Durazzoab Smokers showed greater age-related subcortical brain volume loss than non-smokers. In these adults, 22–70 years of age, older smokers showed the most volume loss. Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human