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They shouldn’t bank on major profits from programmatic fees. The company already handles programmatic buying in-house and plans to expand the model globally, Mr. Herscovici said. WPP reportedly isn’t ready to give up its 24.7% stake in Japanese ad agency Asatsu-DK for the ¥152 billion ($1.35 billion) price private-equity firm Bain Capital has offered for the company. People close to WPP said the tender “severely undervalues” the Japanese firm. [ Financial Times ] EMarketer has lowered its 2017 ad revenue forecast for Snapchat. The research firm now thinks Snapchat will generate $774.1 million in ad revenue world-wide this year, down from its March prediction of $900 million. [ eMarketer ] Those aforementioned Russian entities reportedly used Facebook’s Custom Audiences retargeting tool to identify voters susceptible to being influenced and repeatedly send them ads. [ The Washington Post ] Articles on Gawker.com risk being deleted when it is sold to a new owner. The site could be valuable to a person who wants contentious articles about themselves, their companies or their associates removed from the web. [ WSJ ] Digital wholesaler Boxed is launching a real-time auction platform for its top sponsored search results.

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Drug and Alcohol Dependence Volume 177 , 1 August 2017, Pages 268-276 Reward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation Author links open overlay panel Kathleen A.Garrisona One of the first longitudinal fMRI studies of smoking cessation treatment in adolescents. Adolescents show increased non-drug reward-related brain activity pre- to post-treatment. Increases in reward-related brain activity were associated with smoking abstinence. Tobacco use is often initiated during adolescence and continued into adulthood despite desires to quit. A better understanding of the neural correlates of abstinence from smoking in adolescents may inform more effective smoking cessation interventions. Neural reward systems are implicated in tobacco use disorder, and adolescent smokers have shown reduced reward-related ventral striatal activation related to increased smoking. The current study evaluated nondrug reward anticipation in adolescent smokers using a monetary incentive delay task in fMRI pre- and post- smoking cessation treatment (n = 14). This study tested how changes in neural responses to reward anticipation pre- to post-treatment were related to reduced smoking. An exploratory analysis in a larger sample of adolescents with only pre-treatment fMRI (n = 28) evaluated how neural responses to reward anticipation were related to behavioral inhibition and behavioral activation scales.

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Drug and Alcohol Dependence We observed a significant decline in the use of varenicline after the passage of BBW. The BBW was not associated with decline in the use of bupropion. Passage of BBW may have a substantial impact on the utilization of certain medications. In 2009, the FDA required a black box warning (BBW) on bupropion and varenicline, the two commonly prescribed smoking cessation agents due to reports of adverse neuropsychiatric events. We investigated if there was a decline in use of bupropion and varenicline after the BBW by comparing the percent using these medications before and after BBW. We conducted a retrospective observational study using data from the Medical Expenditure Panel Survey from 2007 to 2014. The study sample consisted of adult smokers, who were advised by their physicians to quit smoking. We divided the time period into “pre-warning”, “post-warning: immediate”, and “post-warning: late.” Unadjusted analysis using chi-square tests and adjusted analyses using logistic regressions were conducted to evaluate the change in bupropion and varenicline use before and after the BBW. Secondary analyses using piecewise regression were also conducted. On an average, 49.04% of smokers were advised by their physicians to quit smoking. We observed a statistically significant decline in varenicline use from 22.1% in year 2007 to 9.23% in 2014 (p value < 0.001).

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